Volume 20, Issue 1, March 2004

Feature Article

GHRELIN A NEW HORMONE IMPLICATED IN THE REGULATION OF GROWTH HORMONE SECRETION AND BODY ENERGY HOMEOSTASIS

Felipe F.Casanueva, MD, PhD; Carlos Dieguez, MD, PhD

Growth hormone (GH) has a complex regulation with two antagonistic hypothalamic hormones, growth hormone releasing hormone (GHRH) and somatostatin, as well as the liver-derived hormone IGF-I. Perhaps the old name of somatotrophic hormone (STH) is more coherent than GH, as this hormone is tightly regulated by the metabolic milieu; additionally, this regulation appears to be superimposed over the classical regulation by peptide hormones. The recently discovered hormone, ghrelin, may well be the bridge connecting somatic growth with general metabolism.

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From the Editor’s Desk

Abstracts

Low-Carbohydrate Diet, Weight Loss and Cardiovascular Risk

Interactions in Gene Encoding Mutations Leading to Cortisone Reductase Deficiency

Anorectic Effects of PYY in Obesity

A Gene Regulator of Puberty

Growth Hormone Effects on Quality of Life of Young Adults

Non-Hormonal Genetic Influence on Brain Development

IGF, Learning & Memory

Beta Cell Capacity and Insulin Sensitivity in Prepubertal Children Born Small for Gestational Age

Letter to the Editor: Preterm Birth Weight and Insulin Resistance at Adolescense