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Figure |
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Leanness, Extended
Lifespan & IGF-I Receptor Mutations in Mice: Fascinating Observations |
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Volume 19,
Issue 2, 2003 |
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Lifespan extension in Igf1r+/- mice with respect to
Igf1r+/+ (WT) mice. |
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a -
Igf1r+/-
females (thick line) live a mean of 33% longer than their wild-type
littermates (756 ± 46 compared with 568 ± 49 days; P < 0.01, t-test).
Kaplan-Meier analysis of survival revealed a later decline in Igf1r+/-
mice compared with wild type (P < 0.001, Cox's test). b -
Igf1r+/- males live 15.9% longer than wild-type littermates
(679 ± 80 compared with 585 ± 69 days; NS). |
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Reprint with permission
from: Holzenberger M, et al. Nature, 2003;421:182-187. |
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