Sampling

What was the population sampled?

What proportion of potential participants were studied?

How do the participants compare to the nonparticipants?

How would results change if nonparticipants have different outcome?

What was the comparison group?

Were the samples of intersex and comparison individuals large enough to see effects of clinical significance, including group differences and predictors of outcome?

 

Outcome Assessment

Were different aspects of outcome carefully differentiated?

    For example, was gender identity measured independently of gender role?

Was each outcome assessed in detail with reliable and valid measures?

Were patients compared to controls to be sure that outcome is specific to an intersex condition?

Were hypothesized predictors of outcome assessed in detail with reliable and valid measures?

 

Inferences

Were appropriate statistical comparisons made so that inferences can be made to the population?

To what populations can results be generalized?

Can outcome be empirically attributed to intersex condition itself?

Can outcome be empirically attributed to specific factors related or unrelated to intersex condition?

Are inferences appropriately qualified in light of (inevitable) methodological limitations?