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Volume 18, Issue 4, December 2002

Feature Article

THE CURRENT FRONTIERS OF IN VITRO FERTILIZATION

Prior to IVF it was common for physicians who treated infertility patients to tell them that everything had been tried, and it was now time to consider adoption or a childless future.  Basic IVF technology changed much of that, as did the addition of donor gametes for those prepared to accept alien genetic material; the physician is now able to offer an option to essentially all couples.  The era of IVF also has made it possible to go beyond the mere solution of the problem of infertility.  Preimplantation genetic diagnosis now makes it possible to eliminate disease-causing mutant genes.  Thus, we are beginning to diminish the number of children born with handicaps.  Such children previously were thought to represent an intrinsic risk of bearing children.

Howard W. Jones, Jr., MD

 

Abstracts from the literature

 
Insulin-like Growth Factor I and Leptin in Umbilical Cord Plasma and Infant Birth Size at Term
 
A Longitudinal Study of the Effects of a Gluten-Free Diet on Glycemic Control and Weight Gain in Subjects With Type 1 Diabetes and Celiac Disease
 
A Gene as a Major Cause of Sotos Syndrome has been Identified
 
Growth and Maturation in Marfan Syndrome
 
Risk for Abnormal Outcomes is Increased with Assisted Reproductive Technology
 
Genetic Screening for Maternal Uniparental Disomy of Chromosome 7 in Prenatal and Postnatal Growth Retardation of Unknown Cause
 
Placental-Specific IGF-II is a Major Modulator of Placental and Fetal Growth
 
Hypovitaminosis D Prevalence and Determinants Among African American and White Women of Reproductive Age:  Third National Health and Nutrition Examination Survey, 1988-1994
 
Quality of Life and Self-Esteem in Children Treated for Idiopathic Short Stature
 
Effect of Supplemental Zinc on the Growth and Serum Zinc Concentrations of Prepubertal Children: A Meta-Analysis of Randomized Controlled Trials
 
β-CellSpecific Deletion of the IGF-I Receptor Leads to Hyperinsulinemia and Glucose Intolerance but does not Alter β-Cell Mass
 
β-Cell Expression of IGF-I Leads to Recovery from Type 1 Diabetes
 
Leptin Acts as a Growth Factor on the Chondrocytes of Skeletal Growth Centers
 

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