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Figure |
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Mutations in Ptpn11,
Encoding the Protein Tyrosine Phosphatase
Shp-2 Cause Noonan Syndrome |
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Volume 18,
Issue 2, 2002 |
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PTPN11
organization and SHP-2 domain structure. The coding exons are shown at
the top as numbered filled boxes, and the positions of the ATG and TGA
codons are indicated. The functional domains of the SHP-2 protein,
comprising two tandemly arranged SH2 domains at the N terminus (N-SH2 and
C-SH2) followed by a protein tyrosine phosphatase (PTP) domain, are shown
below. Numbers below the domain structure indicate the amino-acid
boundaries of those domains. |
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Reprinted with permission from
Tartaglia M,
et al. Nat Genet 2001;29:465-468. |
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