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Figure
3 |
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The Endocrine Function of Adipose Tissue |
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Volume 18,
Issue 2, 2002 |
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Figure 3 -
Peroxisome proliferator-activated receptor (PPAR), a member of the
nuclear hormone receptor superfamily, is a ligand-activated
transcription factor. PPAR is central
to adipocyte function, promoting differentiation of preadipocytes to
mature fat cells. PPAR knockout
(-/-) mice have no detectable adipose tissue. PPAR
is endogenously regulated by heat shock proteins, fatty acids
and prostaglandin J derivatives. Its DNA binding requires
heterodimerization with 9 cis-retinoic
acid receptor (RXR) followed by interaction with peroxisome
proliferator response elements (PPRE) on adipocyte target genes. The
insulin sensitizing thiazolidinedione (TZD)
drugs are PPAR ligands whose effects
on insulin signaling are mediated in part through PPAR
stimulation or inhibition of intracellular
adipokines. |
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