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Figure
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The Endocrine Function of Adipose Tissue |
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Volume 18,
Issue 2, 2002 |
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Figure 2 -
In the adipocyte, leptin inhibits lipogenesis by negative regulation
of acetyl-CoA carboxylase, the rate limiting step in fatty acid
synthesis. Leptin stimulates hormone sensitive lipase, which
hydrolyzes triglycerides, diacylglycerols and cholesterol esters and
downregulates lipoprotein lipase, reducing
fatty acids available for lipogenesis. Glucose uptake is
inhibited by leptin, reducing the availability of glycerol-3-phosphate
required for triglyceride synthesis. |
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