|
A
hypothetical model for the secretion and action of
adiponectin.
The synthesis and secretion of adiponectin
is increased by activation of the nuclear receptor PPAR-g, and reduced
by caloric excess, presumably associated with leptin deficiency or
resistance. Once released, adiponectin can
directly increase fatty-acid transport, oxidation and dissipation in
skeletal muscle, reducing the levels of
intramyocellular lipids, thus improving insulin signaling. The
protein can also increase the sensitivity of the hepatocyte to insulin,
either through a direct action, or indirectly by lowering circulating
lipids due to its action on muscle. Thus, administration of
adiponectin can result in improved insulin
sensitivity and glucose tolerance, and can correct hyperglycemia
associated with obesity.
 Saltiel AR.
You are what you secrete. Nature Med 7:887-888,2001. |
